The Merrifield-Simmons index of a GRAPH is defined as the total number of the independent sets of the GRAPH and the Hosoya index of a GRAPH is defined as the total number of the matchings of the GRAPH. In this paper, we give formula for Merrifield-Simmons and Hosoya indices of some classes of cartesian product of two GRAPHs K2×H, where H is a path GRAPH Pn, cyclic GRAPH Cn, or star GRAPH Sn, with n vertices (These are called: ladder GRAPH, PRISM GRAPH, and book GRAPH).